• Hired at L1 -> L2 in February 2025 -> L3 in September 2025
• Subject matter: design of (de novo) antibodies and soluble proxies for multi-pass membrane proteins (MPMPs)
• Types of work: partner projects, large-scale inference, model training, data wrangling, onboarding new hires
• Whitepapers:
  • De novo design of epitope-specific antibodies against soluble and multipass membrane proteins (January 2025)
  • De novo design of hundreds of functional GPCR-targeting antibodies enabled by scaling test-time compute (May 2025)
  • JAM-2: Fully computational design of drug-like antibodies with high success rates (December 2025)

• Advised by Dr. Jason Yim
• Wrote my senior thesis here, titled Symmetric Diffusion Models for Scalable Cyclic Protein Complex Backbone Generation
• 2023 Herchel Smith fellow
• Built by extending a protein structure generative model (FrameDiff)
  • Modified diffusion process and architecture to respect the equivariances of symmetric protein complexes, which makes modeling more efficient
  • Train on symmetric protein complex data from the PDB that I standardized
  • Evaluated unconditional generation via self-consistency: competitive with RFdiffusion in designability, but lagged behind in novelty and diversity
    • See FrameDiff section 5.1 for definitions
  • Also found that designability evaluation was influenced by the training data of the structure prediction model:
    • UF-MuSSe is a fine-tuned version of ESMFold trained on protein complexes
    • I had some models trained on monomers + multimers and others only trained on monomers
    • ESMFold tended to rate monomer-only models higher in designability (of generated complexes) than UF-MuSSe. I think that ESMFold is probably overrating because it too is only trained on monomers and might be picking up a similar failure mode

• Tried Potts models for multiple sequence alignment (MSA) clustering
• 2022 summer HCRP fellow

• Studied evolutionary dynamics of E. coli in long-term stationary phase (experimental & computational)
• 2021 PRISE fellow

• if you want course planning help please reach out, I have spreadsheets and I love doing it
• Courses were taken at Harvard, undergraduate-level, and I got As unless otherwise noted
  • pass implies class was taken pass fail. I promise I didn’t fail anything
• Grouped by what requirements they counted for
• CPB = Chemical and Physical Biology

Awards: summa cum laude, 3x John Harvard Scholar, Detur Book Prize, Sophia Freund Prize

• Took & got 5s on 13 APs:
  • 9th: Chemistry
  • 10th: Calculus AB, Statistics (self-study)
  • 11th: Biology, Calculus BC, Computer Science A, English Language and Composition, Physics: Mechanics
  • 12th (online due to COVID): English Literature and Composition, Macroeconomics, Microeconomics, Psychology
• Dual-enrolled at a local community college in 12th grade for Multivariate Calculus and Differential Equations.
• Standardized Tests
  • SAT: 1600 (once per school year for 8th - 11th grade, 1520 -> 1520 -> 1570 -> 1600)
  • ACT: 36 (once per school year from 7th - 10th grade, 32 -> 35 -> 36 -> 36)
  • Subject tests: 800 on Math Level 2, Biology, Chemistry, Physics, 780 on Math Level 1
  • PSAT: 1470 (10th) -> 1490 (11th)

• TF = teaching fellow: teach section, grade, hold office hours
• CA = course assistant: mainly office hours

• College
  • Percussionist in the Harvard-Radcliffe Orchestra
  • For fun:
    • The Offering by Michael Burritt (video)
    • Violin Partita No. 2 in D minor by J. S. Bach, Allemande (video)
• High school
  • Marching band (marimba), concert band (percussion), orchestra (timpani)
  • Also played in Detroit Symphony Youth Orchestra & Wind Ensemble senior year
  Awards

  • 3x MSBOA All-State, 1st chair orchestra in 2023
  • North Oakland concerto competition winner (Prism Rhapsody, marimba)

  In school:

  • Front ensemble section leader
  • 1st chair in concert band
  • Department award
  Most of my solo/duet rep

  • Solos:
    • Rain Dance by Alice Gomez
    • Preludio No. 1 by Ney Rosauro
    • Dream of the Cherry Blossoms by Keiko Abe
  • Concertos/concertinos:
    • Concertino for Xylophone and Orchestra by Toshiro Mayuzumi (mvts. 1 & 2)
    • Concerto No. 2 for Marimba and Orchestra by Ney Rosauro, mvt. 2 (video)
    • Prism Rhapsody by Keiko Abe (partial audio)
  • NEC audition rep (I did not get in):
    • Marimba: Violin Partita No. 2 in D minor by J. S. Bach, Gigue (video)
    • Snare: Etude No. 1 from Douze Etudes pour Caisse-Claire by Jacques Delecluse (video)
    • Timpani: Exercise No. 57 from Modern Method for Timpani by Saul Goodman (video)
  • Duets:
    • 2+1 (2 players on 1 marimba)
    • Verve (marimba + bass clarinet)

• Running (since late 2022)
  • 5K: PR 24:29 (2024)
  • Half-Marathon: 1:56:39 (2023) -> 1:49:49 (2024)
  • Marathon: 4:07:07 (2025)
• Lifting (since late 2024)
• Played a lot of intramurals in Quincy House at Harvard my last two years
  • especially ultimate frisbee (Spring 2024 intramural champions!)
  • Also was a practice player for Harvard Bredline for a bit
  • Was an IM house rep my senior year and received a Quincy Scroll and David A. Aloian-Robert L. Beal Award “for significant contributions to the quality of life of the Quincy House Community”
• 2017 JV tennis benchwarmer

Grew up doing math contests, learned at ICAE

Highlights:

• 2023 Putnam: 42/120
• 2x USAJMO qualifier (2017, 2018): 11/42 -> 12
• 6x AIME qualifier (2015 - 2020): 5/15 -> 5 -> 10 -> 10 -> 6 -> 9
• Math department award in high school
• 2016 MathCounts State Champion

• 2x USNCO Honors (2019, 2020)

College:

• GUSH (2020-2023), president 2022-2023
• Harvard-Radcliffe Orchestra (2020-2024), percussionist sometimes
• Cambridge Afterschool Program (2021-2023), volunteer tutor

High school:

• HOSA (2016-2020), medical math competitor, president 2019-2020
• Math club (2016-2020), math competitor, president 2018-2020
• National Honor Society (2018-2020), president 2019-2020
• DECA (2019-2020), business finance series
• ACEing Autism tennis clinic volunteer